Recurrent aseptic meningitis secondary to intracranial epidermoids. Mollaret meningitis, recurrent aseptic meningitis, fever. Difficult and recurrent meningitis journal of neurology. Mollaret meningitis article about mollaret meningitis by. Failure of colchicine in the treatment of mollarets. It was named for pierre mollaret, the french neurologist who first described it. Mollaret meningitis synonyms, mollaret meningitis antonyms. Diagnosis of mollaret meningitis mollaret meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever. Because it may resolve spontaneously, the role of antiviral therapy in mollarets meningitis is often questioned. Because it may resolve spontaneously, the role of antiviral therapy in mollaret s meningitis. Secondary meningitis is that which develops following direct entry of bacteria into the central nervous system, which can occur at the time. Mollaret meningitis the turkish journal of pediatrics.
Pdf herpes simplex virus type 2 mollarets meningitis. Mollaret meningitis is a rare disease characterized by recurrent and selflimited episodes of aseptic meningitis. Nov 01, 2006 recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of aseptic meningitis. Jan 01, 2000 mollarets meningitis is an unusual but perhaps underappreciated syndrome of benign, recurrent, aseptic meningitis. Hence, the name mollaret meningitis is frequently associated with the syndrome. However, recent research and studies have suggested that it may be more common than initially thought. The triangle of guillain and mollaret, also known as the dentatorubroolivary pathway, has three corners 1 red nucleus. It is characterized by repeated episodes of meningitis, typically lasting two to.
In many ways it resembles recurrent hereditary polyserositis familial mediterranean fever in its natural history, pattern of attacks, and response to colchicine. The features of these activated monocytes were compatible with those of mollarets cells, and csf herpes simplex virus type 2 hsv2 pcr assay. A 72yearold woman, previously in good health, suffered for 2 years from attacks of a complex neuropsychiatric syndrome lasting from 2 days to 4 weeks. Recurrent meningitis association provider information. The guillainmollaret triangle in action practical neurology. In 1 case of mollaret meningitis, 2 of the 5 attacks were druginduced thilmann et al 1991. The disease is characterized by repeated episodes of fever and signs of meningeal inflammation that usually subside within 25 days after onset. Mollarets meningitis is a rare condition with a characteristic clinical and cerebrospinal fluid picture. Kinohshita t, matsushima a, satoh s, et al 2014 a case of colchicineresponsive mollaret s meningitis. Mollarets meningitis benign recurrent aseptic meningitis. Herpes simplex virus type 2associated recurrent aseptic mollarets. The disease is characterised by recurrent at least three episodes, benign no longterm sequelae and brief 25 day episodes of aseptic lymphocytic meningitis. When initially described by mollaret, this form of aseptic meningitis had no identifiable.
For one of these cases, the episodes of meningitis were associated with herpetic outbreaks. The etiology of mollaret meningitis, a recurrent form of aseptic meningitis, is not clear mollaret 1944. Jan 25, 2019 mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Table 1 causes of an aseptic meningitis cerebrospinal fluid picture in this article, the major causes of meningitis. The prophylactic efficacy of drugs in mollaret s meningitis. Mollaret s meningitis mm is a rare disease of benign nature characterized by recurrent episodes of aseptic meningitis. In recent years there has been increasing evidence to implicate the herpes simplex virus 2 hsv2 in many cases. Table 1 causes of an aseptic meningitis cerebrospinal fluid picture in this article, the major causes of meningitis are considered in turn, highlighting the difficulties which may arise under these three headings. A 32yearold man was hospitalized 23 times in 11 years because of attacks of mollaret s meningitis.
Mollaret s meningitis is an unusual and underappreciated syndrome of benign, recurrent aseptic meningitis. Mollaret meningitis is characterized by three or more episodes of benign recurrent aseptic meningitis in which symptoms and signs resolve spontaneously. Mollarets meningitis is a recurrent or chronic inflammation of the protective membranes. Descrita por primera vez en 1944 por pierre mollaret como una meningitis. We report a case of mollaret meningitis in a sevenyearold girl who presented with four aseptic meningitis episodes in one year. Because of its rarity, it is difficult to estimate the exact number of individuals affected by this condition. Las posibles causas incluyen virus del herpes simple tipo 1. Canadian journal of neurological sciences journal canadien des sciences neurologiques, vol. Mollarets meningitis and differential diagnosis of recurrent meningitis. Pdf on oct 1, 2014, zaw min and others published mollarets meningitis find, read and cite all the research you need on researchgate. Mollarets meningitis an overview sciencedirect topics. It has been suggested that if the strict criteria above are followed, these cases should be excluded, and the term mollaret s meningitis reserved for true idiopathic cases.
The disease is characterised by recurrent at least three episodes, benign no longterm sequelae and brief 25 day episodes of aseptic lymphocytic meningitis, alternating with symptomfree interval, mostly caused by hsv2 infection. Our founder, michael hrehor, was told he had recurrent viral meningitis. Get a printable copy pdf file of the complete article 869k, or click on a page image. Mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. The clinical features in a patient with recurrent brief episodes of aseptic meningitis are described. Pdf mollarets meningitis is an unusual and underappreciated syndrome of benign, recurrent aseptic meningitis.
Until recently, this syndrome had been considered a disease of unknown etiology. Mollarets meningitis and differential diagnosis of recurrent. Most cases of meningitis in the united states are caused by a viral infection, but bacterial, parasitic and fungal infections are other causes. Mollaret syndrome definition of mollaret syndrome by. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion. Synonyms for mollaret meningitis in free thesaurus.
Aseptic meningitis often has a similar presentation to that of bacterial meningitis ie, fever, headache, altered mental status, stiff neck, photophobia, which can be a lifethreatening illness. Recurrent herpes simplex type 2 virus mollaret meningitis. Cerebrospinal fluid csf examination remains the sole diagnostic. Meningitis is an inflammation of the membranes meninges surrounding your brain and spinal cord. Mollarets meningitis is a rare form of idiopathic recurrent aseptic meningitis that has a sudden onset, short duration, and spontaneous remission. Should mollarets meningitis always be treated with anti. Mollaret cells, which are a hallmark of mollaret s meningitis. Mollarets meningitis is a rare disease characterized by recurrent, selflimited episodes of aseptic meningitis. Broadly speaking, there are three main potential areas of concern. Mollaret s meningitis associated with acute epstein. When initially described by mollaret, this form of aseptic meningitis had no identifiable infecting agent. Mollaret meningitis was first described by mollaret in 1944 as a form of aseptic meningitis.
We describe three patients with benign recurrent aseptic meningitis mollaret s meningitis. Mollaret meningitis genetic and rare diseases information. The swelling from meningitis typically triggers symptoms such as headache, fever and a stiff neck. O u r p a ti en t r eg i str y w i l l b e l i v e th e en d of 2 0 1 8 a n d w e h op e to h a v e th e f i r st r esu l ts f r om.
Descrita por primera vez en 1944 por pierre mollaret como una meningitis endoteliolinfocitica recurrente caracterizada por presentarse en pacientes por lo demas sanos. Should mollarets meningitis always be treated with antihsv. Mollarets meningitis is a rare complication of herpes simplex virus. It is characterized by repeated episodes of meningitis, typically lasting two to five days, occurring weeks to years apart. Mollarets meningitis is a rare form of benign, recurrent aseptic meningitis characterized by the appearance of a particular mononuclear cell in the csf during the first few days of the illness. Since mollaret s meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred to as benign recurrent lymphocytic meningitis. Mollarets meningitis associated with herpes simplex type. In addition to symptoms typical of meningitis, patients may also have. The guillainmollaret triangle comprises the ipsilateral red nucleus in the midbrain, the inferior olive in the medulla and the contralateral dentate nucleus in the cerebellum. When can the management of meningitis become difficult.
Pdf mollarets meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. The recurrent meningitis association was started because there was a need to advocate for those with recurrent viral meningitis. They were identical to those in an entity known as mollarets. This syndrome is associated with tra we use cookies to enhance your experience on our website. Common signs and symptoms during an episode may include severe headache, fever, nausea, vomiting, sensitivity to light photophobia, and stiff neck. Sep 02, 2016 mollaret meningitis is thought to be rare. Mollaret meningitis is a rare form of meningitis that is recurrent, aseptic, mild, and selflimiting. Kinohshita t, matsushima a, satoh s, et al 2014 a case of colchicineresponsive mollarets meningitis with mefv gene mutation. Mollaret s meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Analysis of candidatehost immunogenetic determinants in.
Recurrent benign lymphocytic meningitis clinical infectious. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and. Twentyeight years of benign recurring mollaret meningitis. Secondary meningitis is that which develops following direct entry of bacteria into the central nervous system, which can occur at the time of neurosurgery, in association with trauma, or through an abnormal communication between the external environment and the. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Mollarets meningitis the lancet infectious diseases. As stated by many authors, mollaret s meningitis should only be referred to recurrent aseptic meningitis with unknown aetiology after throughout studies including molecular tehcniques. Recurrent meningitis association provider information recurrent viral meningitis mollaret s. Jun 06, 2006 mollaret cells have also been described in reports of various other diseases, such as west nile virus infection, sarcoidosis and behcets disease. However, in contrast to bacterial meningitis, many patients with aseptic meningitis. As stated by many authors, mollarets meningitis should only be referred to recurrent aseptic meningitis with unknown aetiology after throughout studies including molecular tehcniques.
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